Xianlin Han Selected Research

Cardiolipins (Cardiolipin)

11/2020	Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes.
1/2020	Cardiolipin deficiency elevates susceptibility to a lipotoxic hypertrophic cardiomyopathy.
1/2020	The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats.
1/2020	Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease.
1/2020	The mitochondria-targeted peptide SS-31 binds lipid bilayers and modulates surface electrostatics as a key component of its mechanism of action.
11/2015	Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart.
1/2014	A role for peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) in the regulation of cardiac mitochondrial phospholipid biosynthesis.
1/2014	Unremodeled and remodeled cardiolipin are functionally indistinguishable in yeast.
1/2014	Mitochondria-targeted antioxidant prevents cardiac dysfunction induced by tafazzin gene knockdown in cardiac myocytes.
7/2012	Myocardial regulation of lipidomic flux by cardiolipin synthase: setting the beat for bioenergetic efficiency.

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Xianlin Han Research Topics

Disease

37	Alzheimer Disease (Alzheimer's Disease) 01/2023 - 08/2002
23	Insulin Resistance 01/2022 - 03/2003
20	Obesity 01/2022 - 12/2006
14	Mitochondrial Diseases (Mitochondrial Disease) 10/2021 - 12/2005
12	Neoplasms (Cancer) 10/2021 - 12/2008
10	Cognitive Dysfunction 01/2022 - 12/2009
9	Inflammation (Inflammations) 06/2022 - 08/2010
9	Cardiomyopathies (Cardiomyopathy) 01/2020 - 01/2002
6	Non-alcoholic Fatty Liver Disease 01/2022 - 09/2011
6	Dementia (Dementias) 11/2021 - 08/2002
5	Fibrosis (Cirrhosis) 01/2022 - 11/2013
5	Barth Syndrome 01/2020 - 11/2013
5	Type 2 Diabetes Mellitus (MODY) 01/2020 - 12/2006
5	Brain Injuries (Brain Injury) 12/2018 - 03/2003
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2016 - 11/2007
5	Diabetic Cardiomyopathies 05/2007 - 01/2002
4	Hyperglycemia 01/2022 - 10/2012
4	Neuroinflammatory Diseases 01/2021 - 12/2010
4	Ischemia 01/2020 - 06/2003
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 12/2021 - 12/2007
3	Insulinoma 06/2021 - 06/2018
3	Systemic Lupus Erythematosus (Libman-Sacks Disease) 02/2021 - 12/2016
3	Diabetes Mellitus 11/2020 - 01/2002
3	Pancreatic Neoplasms (Pancreatic Cancer) 02/2020 - 05/2014
3	Cardiomegaly (Heart Hypertrophy) 01/2020 - 02/2003
3	Inborn Genetic Diseases (Disease, Hereditary) 01/2020 - 12/2007
3	Atrophy 11/2019 - 01/2019
3	Disease Progression 01/2017 - 07/2012
3	Hypertrophy 11/2013 - 01/2002
2	Dyslipidemias (Dyslipidemia) 01/2022 - 01/2020
2	Overweight 01/2022 - 04/2020
2	Atherosclerosis 08/2021 - 10/2007
2	Adenocarcinoma 04/2021 - 01/2021
2	Diabetic Neuropathies (Diabetic Neuropathy) 11/2020 - 06/2006
2	Hyperlipidemias (Hyperlipidemia) 11/2020 - 02/2005
2	Brain Neoplasms (Brain Tumor) 01/2020 - 12/2008
2	Amyloid Plaque 01/2017 - 01/2004
2	Thrombosis (Thrombus) 12/2016 - 09/2010

Drug/Important Bio-Agent (IBA)

53	LipidsIBA 01/2023 - 08/2002
16	Phospholipids (Phosphatides)FDA LinkGeneric 06/2022 - 06/2003
16	Glucose (Dextrose)FDA LinkGeneric 01/2022 - 01/2002
14	Biomarkers (Surrogate Marker)IBA 11/2022 - 07/2003
14	Cardiolipins (Cardiolipin)IBA 11/2020 - 12/2005
13	Fatty Acids (Saturated Fatty Acids)IBA 11/2018 - 01/2002
12	Sulfoglycosphingolipids (Sulfatides)IBA 01/2021 - 08/2002
10	Apolipoproteins E (ApoE)IBA 11/2022 - 03/2003
10	Proteins (Proteins, Gene)FDA Link 08/2017 - 03/2003
9	Insulin (Novolin)FDA Link 01/2022 - 11/2010
8	Amyloid (Amyloid Fibrils)IBA 01/2021 - 07/2010
8	EnzymesIBA 12/2019 - 03/2003
7	Triglycerides (Triacylglycerol)IBA 01/2022 - 02/2003
7	CeramidesIBA 01/2020 - 08/2002
6	Amyloid beta-PeptidesIBA 01/2021 - 01/2004
5	ApolipoproteinsIBA 11/2022 - 06/2010
5	Phosphatidylcholines (Phosphatidylcholine)IBA 01/2022 - 11/2012
5	PlasmalogensIBA 11/2020 - 08/2002
5	Peptides (Polypeptides)IBA 01/2020 - 08/2008
4	Acyl Coenzyme A (Acyl CoA)IBA 06/2022 - 09/2005
4	DiglyceridesIBA 01/2022 - 11/2010
4	Adenosine Triphosphate (ATP)IBA 01/2022 - 07/2008
4	CholesterolIBA 01/2020 - 10/2007
4	CalciumIBA 11/2019 - 06/2003
4	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 11/2019 - 01/2002
4	Calcium-Independent Phospholipases A2IBA 11/2010 - 06/2003
4	PPAR alphaIBA 12/2007 - 01/2002
3	Arachidonic Acid (Vitamin F)IBA 06/2022 - 12/2021
3	Protein Isoforms (Isoforms)IBA 01/2021 - 09/2004
3	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2020 - 01/2014
3	arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamideIBA 01/2020 - 11/2015
3	Phosphatidylinositols (Phosphatidylinositol)IBA 12/2016 - 07/2003
3	Phospholipases (Phospholipase)IBA 11/2010 - 06/2003
3	SphingolipidsIBA 01/2009 - 03/2003
2	Ligases (Synthetase)IBA 06/2022 - 12/2021
2	IronIBA 01/2022 - 07/2011
2	Lysophosphatidylcholines (Lysophosphatidylcholine)IBA 01/2022 - 06/2003
2	Amino Acids FDA Link 01/2022 - 01/2022
2	Ether (Diethyl Ether)IBA 01/2022 - 12/2007
2	Messenger RNA (mRNA)IBA 01/2022 - 03/2009
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 12/2021 - 01/2017
2	Apolipoprotein E4IBA 11/2021 - 05/2007
2	Dietary Fats (Dietary Fat)IBA 10/2021 - 02/2003
2	Antigen-Antibody Complex (Immune Complex)IBA 02/2021 - 01/2017
2	Pharmaceutical PreparationsIBA 01/2021 - 01/2014
2	Lipoproteins (Lipoprotein)IBA 01/2021 - 08/2010
2	bis(monoacylglyceryl)phosphateIBA 01/2021 - 05/2015
2	LeptinIBA 12/2020 - 01/2020
2	Apolipoprotein E2IBA 10/2020 - 05/2016
2	Biological ProductsIBA 04/2020 - 12/2016
2	Nonesterified Fatty Acids (NEFA)IBA 01/2020 - 01/2018
2	RNA (Ribonucleic Acid)IBA 01/2020 - 01/2017
2	Blood Glucose (Blood Sugar)IBA 12/2019 - 01/2016
2	Bile Acids and Salts (Bile Acids)IBA 01/2019 - 01/2019
2	PhosphatidylglycerolsIBA 01/2019 - 11/2010
2	AntigensIBA 01/2019 - 06/2012
2	AcyltransferasesIBA 01/2019 - 08/2010
2	Anesthetics (Anesthetic Agents)IBA 01/2018 - 01/2018
2	Membrane LipidsIBA 12/2016 - 12/2013

Therapy/Procedure

3	Therapeutics 03/2019 - 12/2007
2	Pancreaticoduodenectomy 01/2021 - 01/2021
2	Glycemic Control 11/2020 - 11/2019